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Vitamin C effective in targeting cancer stem cells

Vitamin C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists in Salford, UK. The research, published in  Oncotarget , is the first evidence that Vitamin C (ascorbic acid) can be used to target and kill cancer stem cells (CSCs), the cells responsible for fuelling fatal tumours. Dr Michael P. Lisanti, Professor of Translational Medicine at the University of Salford, said: "We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey-bee derivative, but by far the most exciting are the results with Vitamin C. "Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step." Cancer stem-like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and ...

Neuroscientists pinpoint key gene controlling tumor growth in brain cancers

To enhance understanding of how glioma cancer stem cells (GCSCs) reproduce and how they affect patient survival, investigators spent three years analyzing the genetic makeup of more than 4,000 brain tumors. During their investigation, they identified the gene, called ZEB1, that regulates tumor growth. The investigators' analysis suggests that brain cancer patients who don't have the gene tend to have lower survival rates. "Patients without the gene in their tumors have more aggressive cancers that act like stem cells by developing into an uncontrollable number of cell types," said John Yu, MD, vice chair of neurosurgical oncology in the Department of Neurosurgery and senior author of the study. "This new information could help us to measure the mutation in these patients so that we are able to provide a more accurate prognosis and treatment plan." Brain cancer occurs when cancer cells -- also called malignant cells -- arise in the brain tissue. This ye...

The intestine has a reservoir of stem cells that are resistant to chemotherapy

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After Chemotherapy , these cells change their behaviour, change into lively and regenerate all cell varieties within the gut (in inexperienced). Credit score: Franscisco Barriga, IRB Barcelona The gut has a excessive price of mobile regeneration as a result of put on and tear originated by its operate degrading and absorbing vitamins and eliminating waste. The complete cell wall is renewed as soon as per week roughly. This explains why the gut holds a lot of stem cells in fixed division, thereby producing new cell populations of the varied varieties current on this organ. Researchers on the Institute for Analysis in Biomedicine (IRB Barcelona) headed by ICREA investigator Eduard Batlle, head of the Colorectal Most cancers Laboratory, have found a brand new group of intestinal stem cells with very totally different traits to these of the plentiful and lively stem cells already recognized on this organ. Carried out in collaboration with the Centro ...